Online context recognition in multisensor systems using Dynamic Time Warping

In this paper, we present our system for online context recognition of multimodal sequences acquired from multiple sensors. The system uses Dynamic Time Warping (DTW) to recognize multimodal sequences of different lengths, embedded in continuous data streams. We evaluate the performance of our system on two real world datasets: 1) accelerometer data acquired from performing two hand gestures and 2) NOKIA\u27s benchmark dataset for context recognition. The results from both datasets demonstrate that the system can perform online context recognition efficiently and achieve high recognition accuracy.<br /

Temporal data fusion in multisensor systems using dynamic time warping

Data acquired from multiple sensors can be fused at a variety of levels: the raw data level, the feature level, or the decision level. An additional dimension to the fusion process is temporal fusion, which is fusion of data or information acquired from multiple sensors of different types over a period of time. We propose a technique that can perform such temporal fusion. The core of the system is the fusion processor that uses Dynamic Time Warping (DTW) to perform temporal fusion. We evaluate the performance of the fusion system on two real world datasets: 1) accelerometer data acquired from performing two hand gestures and 2) NOKIA&rsquo;s benchmark dataset for context recognition. The results of the first experiment show that the system can perform temporal fusion on both raw data and features derived from the raw data. The system can also recognize the same class of multisensor temporal sequences even though they have different lengths e.g. the same human gestures can be performed at different speeds. In addition, the fusion processor can infer decisions from the temporal sequences fast and accurately. The results of the second experiment show that the system can perform fusion on temporal sequences that have large dimensions and are a mix of discrete and continuous variables. The proposed fusion system achieved good classification rates efficiently in both experiments<br /

Device Integrity of Drug-eluting Depot Stent for Smart Drug Delivery

Atherosclerosis, or hardening of the arteries, is a condition in which plaque, made of cholesterol, fatty substances, cellular waste products, calcium, and fibrin, builds up inside the arteries. A metallic stent is a small mesh tube that is used to treat these narrowed arteries such as coronary artery diseases. The drug-eluting stent has a metallic stent platform coated with drug-polymer mix and has been shown to be superior to its metallic stent counterpart in reducing restenosis. In the past few years, a novel variation of the drug-eluting stent with micro-sized drug reservoirs (depot stent) has been introduced to the market. It allows smart programmable drug delivery with spatial/temporal control and has potential advantages over conventional stents. The drug-polymer mix compound can be altered from one reservoir to the next, allowing a highly-controlled release of different medications. For example, this depot stent concept can be applied in the renal indication for potential treatment of both renal artery stenosis (upstream) and its associated kidney diseases (downstream) simultaneously. However, the creation of such drug reservoirs on the stent struts inevitably compromises its mechanical integrity. In this study, the effects of these drug reservoirs on stent key clinical attributes were systematically investigated. We developed finite element models to predict the mechanical integrity of a balloon-expandable stent at various stages of its function life such as manufacturing and acute deployment, as well as the stent radial strength and chronic fatigue life. Simulation results show that (1) creating drug reservoirs on a stent strut could impact the stent fatigue resistance to certain degrees; (2) drug reservoirs on the high stress concentration regions led to much greater loss in all key clinical attributes than reservoirs on other locations; (3) reservoir shape change resulted in little differences in all key clinical attributes; and (4) for the same drug loading capacity, larger and fewer reservoirs yielded higher fatigue safety factor. These results can help future stent designers to achieve the optimal balance of stent mechanical integrity and smart drug delivery, thereby opening up a wide variety of new opportunities for disease treatments. We also proposed an optimized depot stent with tripled drug capacity and acceptable marginal trade-off in key clinical attributes when compared to the current drug-eluting stents. This depot stent prototype was manufactured for the demonstration of our design concept

An integrated omics analysis reveals molecular mechanisms that are associated with differences in seed oil content between Glycine max and Brassica napus

Abstract Background: Rapeseed (Brassica napus L.) and soybean (Glycine max L.) seeds are rich in both protein and oil, which are major sources of biofuels and nutrition. Although the difference in seed oil content between soybean (~ 20%) and rapeseed (~ 40%) exists, little is known about its underlying molecular mechanism. Results: An integrated omics analysis was performed in soybean, rapeseed, Arabidopsis (Arabidopsis thaliana L. Heynh), and sesame (Sesamum indicum L.), based on Arabidopsis acyl-lipid metabolism- and carbon metabolism-related genes. As a result, candidate genes and their transcription factors and microRNAs, along with phylogenetic analysis and co-expression network analysis of the PEPC gene family, were found to be largely associated with the difference between the two species. First, three soybean genes (Glyma.13G148600, Glyma.13G207900 and Glyma.12G122900) co-expressed with GmPEPC1 are specifically enriched during seed storage protein accumulation stages, while the expression of BnPEPC1 is putatively inhibited by bna-miR169, and two genes BnSTKA and BnCKII are co-expressed with BnPEPC1 and are specifically associated with plant circadian rhythm, which are related to seed oil biosynthesis. Then, in de novo fatty acid synthesis there are rapeseed-specific genes encoding subunits β-CT (BnaC05g37990D) and BCCP1 (BnaA03g06000D) of heterogeneous ACCase, which could interfere with synthesis rate, and β-CT is positively regulated by four transcription factors (BnaA01g37250D, BnaA02g26190D, BnaC01g01040D and BnaC07g21470D). In triglyceride synthesis, GmLPAAT2 is putatively inhibited by three miRNAs (gma-miR171, gma-miR1516 and gma-miR5775). Finally, in rapeseed there was evidence for the expansion of gene families, CALO, OBO and STERO, related to lipid storage, and the contraction of gene families, LOX, LAH and HSI2, related to oil degradation. Conclusions: The molecular mechanisms associated with differences in seed oil content provide the basis for future breeding efforts to improve seed oil content

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Using dynamic time warping for multi-sensor fusion

Fusion is a fundamental human process that occurs in some form at all levels of sense organs such as visual and sound information received from eyes and ears respectively, to the highest levels of decision making such as our brain fuses visual and sound information to make decisions. Multi-sensor data fusion is concerned with gaining information from multiple sensors by fusing across raw data, features or decisions. The traditional frameworks for multi-sensor data fusion only concern fusion at specific points in time. However, many real world situations change over time. When the multi-sensor system is used for situation awareness, it is useful not only to know the state or event of the situation at a point in time, but also more importantly, to understand the causalities of those states or events changing over time.Hence, we proposed a multi-agent framework for temporal fusion, which emphasises the time dimension of the fusion process, that is, fusion of the multi-sensor data or events derived over a period of time. The proposed multi-agent framework has three major layers: hardware, agents, and users. There are three different fusion architectures: centralized, hierarchical, and distributed, for organising the group of agents. The temporal fusion process of the proposed framework is elaborated by using the information graph. Finally, the core of the proposed temporal fusion framework – Dynamic Time Warping (DTW) temporal fusion agent is described in detail.Fusing multisensory data over a period of time is a challenging task, since the data to be fused consists of complex sequences that are multi–dimensional, multimodal, interacting, and time–varying in nature. Additionally, performing temporal fusion efficiently in real–time is another challenge due to the large amount of data to be fused. To address these issues, we proposed the DTW temporal fusion agent that includes four major modules: data pre-processing, DTW recogniser, class templates, and decision making. The DTW recogniser is extended in various ways to deal with the variability of multimodal sequences acquired from multiple heterogeneous sensors, the problems of unknown start and end points, multimodal sequences of the same class that hence has different lengths locally and/or globally, and the challenges of online temporal fusion.We evaluate the performance of the proposed DTW temporal fusion agent on two real world datasets: 1) accelerometer data acquired from performing two hand gestures, and 2) a benchmark dataset acquired from carrying a mobile device and performing pre-defined user scenarios. Performance results of the DTW based system are compared with those of a Hidden Markov Model (HMM) based system. The experimental results from both datasets demonstrate that the proposed DTW temporal fusion agent outperforms HMM based systems, and has the capability to perform online temporal fusion efficiently and accurately in real–time

Using dynamic time warping for online temporal fusion in multisensor systems

Sensor fusion is concerned with gaining information from multiple sensors by fusing across raw data, features or decisions. Traditionally these fusion processes only concern fusion at specific points in time. However recently, there is a growing interest in inferring the behavioural aspects of environments or objects that are monitored by multisensor systems, rather than just their states at specific points in time. In order to infer environmental behaviours, it may be necessary to fuse data acquired from (i) geographically distributed sensors at specific points of time and (ii) specific sensors over a period of time. Fusing multisensor data over a period of time (also known as Temporal fusion) is a challenging task, since the data to be fused consists of complex sequences that are multi-dimensional, multimodal, interacting, and time-varying in nature. Additionally, performing temporal fusion efficiently in real-time is another challenge due to the large amounts of data to be fused. To address this issue, we propose a robust and efficient framework that uses dynamic time warping (DTW) as the core recognizer to perform online temporal fusion on either the raw data or the features. We evaluate the performance of the online temporal fusion system on two real world datasets: (1) accelerometer data acquired from performing two hand gestures, and (2) a benchmark dataset acquired from carrying a mobile device and performing the predefined user scenarios. Performance results of the DTW-based system are compared with those of a Hidden Markov Model (HMM) based system. The experimental results from both datasets demonstrate that the proposed system outperforms HMM based systems, and has the capability to perform online temporal fusion efficiently and accurately in real-time